Here are some topics, publications, or videos that we are planning to review in future posts. In other words, these are “coming attractions.”
AMYLOID BETA PROCESSING.
This YouTube video on Amyloid Beta processing is oriented toward understanding AD at the cellular level. However, the first portion of the video is extremely useful for those interested in cerebral amyloid angiopathy, and especially the role of secretases in cleaving amyloid precursor protein.
Here is a link: https://www.youtube.com/watch?v=k-xsdP0iswg&t=
UPDATES IN CEREBRAL AMYLOID ANGIOPATHY.
A new YouTube interview with Dr. Charidimou. This interview may be of special interest, in part, because of suggestions that the risks of hemorrhagic stroke recurrence are mainly in selected patients.
Here is a link: https://www.youtube.com/watch?v=v59nMk4uo_I
Some notes from the video:
– Subarchnoid Hemorrhage may lead to cSS
– In patients with possible co-occurence of both CAA and small vessel disease, the presence of cSS (especially mult-focal) may help determine that CAA is present.
– There is a valuable discussion of Amyloid-Pet as a diagnostic marker. It is in general not as good as Boston 2.0 for diagnosis, but a negative result suggests that CAA can be excluded.
– Core Cerebral Spinal Fluid (Core CSF) markers have the potential to provide a panel of AB38, AB40, and AB42 presence.
– The risk of recurrence given a single lobar hemorrhage is about 7% but the confidence intervals are 4% and 10%– which is worth keeping in mind.
– Very importantly, siderosis and age are the ONLY independent predictors of future hemmorhage.
BLOOD BRAIN BARRIER.
This video gives a useful description of the blood brain barrier. It’s function is central to the development of CAA.
Neuropathological correlates of cortical superficial siderosis in cerebral amyloid angiopathy
Here is a link: https://www.youtube.com/watch?v=vZCfTCF4ABo
Brain. 2020 Dec 5;143(11):3343-3351. doi: 10.1093/brain/awaa266.
Neuropathological correlates of cortical superficial siderosis in cerebral amyloid angiopathy
Andreas Charidimou 1 2 , Valentina Perosa 1 , Matthew P Frosch 3 , Ashley A Scherlek 4 , Steven M Greenberg 1 , Susanne J van Veluw 1 4
RESEARCH ON “TRANEXAMIC ACID IN A MOUSE MODEL OF CEREBRAL AMYLOID ANGIOPATHY”
According to this study, tranexamic acid has the potential to reduce bleeding in patients with amyloid angiopathy, while appearing to be safe.
https://www.rpthjournal.org/article/S2475-0379(23)00218-2/fulltext
SECOND GENERATION ANTI-AMYLOID MONOCLONAL ANTIBODIES FOR ALZHEIMERS DISEASE