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What posts may be coming next (if all goes well)?
Here are some topics, publications, or videos that we are planning to review in future posts. In other words, these are “coming attractions.” AMYLOID BETA PROCESSING. This YouTube video on Amyloid Beta processing is oriented toward understanding AD at the cellular level. However, the first portion of the video is extremely useful for those interested…
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Cortical superficial siderosis: –how it effects the risk of recurrence of hemorragic stroke with cerebral amyloid angiopathy
In a YouTube interview on Mar 6, 2023, Dr Andreas Charidimou discussed the significance of cortical superficial siderosis (cSS) for predicting the risk of recurrence of a hemorrhagic stroke in patients with cerebral amyloid angiopathy. Here is a link to the video: https://www.youtube.com/watch?v=b4l0Z0H0f2s Note: The comments most relevant to this blog are at 20:05. According…
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Rage receptors, Taxifolin, Immunotherapy, Cilostazol-Taxifolin, and ApoA-1 as therapeutic targets for CAA
This summary of potential therapeutic targets for treating cerebral amyloid angiopathy is drawn primarily from an important review article, “Models of cerebral amyloid angiopathy-related intracerebral hemorrhage,” published by Sebastian, Vargas-George and Kunjan, R. Dave in “Brain Hemorrhages, Volume 3, Issue 4, December 2022, Pages 189-199.Here is a link to the complete article: https://www.sciencedirect.com/journal/brain-hemorrhages. Editors note:…
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Summary: “Blood–brain barrier leakage and perivascular inflammation in cerebral amyloid angiopathy”
This is a summary of an article by Mariel G Kozberg, Irvin Yi, Whitney M Freeze, Corinne A Auger, Ashley A Scherlek, Steven M Greenberg, Susanne J van Veluw which was published in Brain Communications, Volume 4, Issue 5, 2022, fcac245. It was published on 26 September 2022.Here is a link to the complete article:…
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“Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy”
This is a summary of a very interesting publication, with the same title as above, by Takayuki Inoue (Kyoto Medical Center), Satoshi Saito, Masashi Tanaka and edited by Lawrence Steinman (Stanford University School of Medicine). It was published April 29, 2019 in the Proceedings of the National Academy of Sciences (PNAS) 116 (20) 10031-10038Here is…
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Apolipoprotein A-1 and Amyloid Angiopathy
This research by Terry L. Lewis, Dongfeng Cao, Hailin Lu, et al was motivated by the observation that HDL and its component apolipoprotein A-1 are protective against cardiac disease, on the one hand, and tend to be low in Alzheimer’s Disease patients. In a mouse mode, they have showed that “increasing plasma apoA-I/HDL levels ameliorates…
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Traveling to Altitude with Amyloid Angiopathy
Because of the broad health benefits of being in nature–or merely to benefit once again from pleasures that they had previously enjoyed — many people recovering from cerebral amyloid angiopathy (CAA) may wish to visit mountains, national parks, or other high altitude (HA) locations. HA locations also include cities like Colorado Springs (1,800 meters), or…
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Olive Oil May Reduce Risk of Fatal Dementia by 28%
According to a report by Anne-Julie Tessier, RD, PhD, a postdoctoral fellow at the Harvard T.H. Chan School of Public Health, published by the American Society for Nutrition, consumption of olive oil may reduce the risk of fatal dementia by 28% compared to using such products as margarine, butter, or mayonaise. Here is a link…
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Brain waste clearance to treat CAA: apolipoprotein J (clusterin), and cholinergic and aginergic innervation of the smooth cells
According to Roxana Carare, MD PhD, at the University of Southampton, apolipoprotein J (also called clusterin) is being investigated for its role in chaperoning Amyloid Beta for brain waste clearance along the intramural periarterial pathway (IPAD). A second approach to improving amyloid beta clearance is via the cholinergic and aginergic innervation of the smooth cells…
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List of Expert Researchers in Cerebral Amyloid Angiopathy
Since so much research is currently being conducted on cerebral amyloid angiopathy, it may be useful to know some of the widely published researchers, where they are working, and the themes of their best research papers. Here is a link to findexpertmd.com: https://findexpertmd.com/d/Cerebral_Amyloid_Angiopathy