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Rage receptors, Taxifolin, Immunotherapy, Cilostazol-Taxifolin, and ApoA-1 as therapeutic targets for CAA
This summary of potential therapeutic targets for treating cerebral amyloid angiopathy is drawn primarily from an important review article, “Models of cerebral amyloid angiopathy-related intracerebral hemorrhage,” published by Sebastian, Vargas-George and Kunjan, R. Dave in “Brain Hemorrhages, Volume 3, Issue 4, December 2022, Pages 189-199.Here is a link to the complete article: https://www.sciencedirect.com/journal/brain-hemorrhages. Editors note:…
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Summary: “Blood–brain barrier leakage and perivascular inflammation in cerebral amyloid angiopathy”
This is a summary of an article by Mariel G Kozberg, Irvin Yi, Whitney M Freeze, Corinne A Auger, Ashley A Scherlek, Steven M Greenberg, Susanne J van Veluw which was published in Brain Communications, Volume 4, Issue 5, 2022, fcac245. It was published on 26 September 2022.Here is a link to the complete article:…
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Depression may interfere with blood pressure management after intracerebral hemorrhage
Blood pressure management (which typically means keeping average systolic pressure below 130Hg) is one of the few means of reducing the risk of intracerebral hemorrhage for patients with cerebral amyloid angiopathy (CAA). Yet, less than one-half of patients are able to achieve their necessary blood pressure targets. According to one study at Mass General Hospital,…
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Unraveling microinfarts and microbleeds in cerebral amyloid angiopathy
At Mass General Hospital, Susanne Janneke van Veluw, gives an impressive explanation of the pathophysiology of microinfarts and microbleeds due to CAA. Microinfarts seem to come from blood vessels that retain amyloid-beta, lose smooth muscle cells, and therefore become stiff–possibly leading to an infart. Microbleeds seem to occur when cells lose both amyloid-beta and smooth…
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Apolipoprotein D may be a potential biomarker for CAA
Apolipoprotein D (apoD) is a potential cerebrospinal fluid (CSF) biomarker for cerebral amyloid angiopathy (CAA) since it appears to be associated with CAA in human brain tissue. According to research in the Netherlands, “ApoD was strongly associated with amyloid deposits in vessels, but not with parenchymal plaques [as would be the case for Alzheimers (AD)]….…
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To test or not to test –Cerebral Amyloid Angiopathy (CAA).
CAA is a serious age-related condition that may be discovered only after a hemorrhagic stroke followed by an MRI. Since MRI’s are not exceedingly expensive, why not test seniors (over age 75 for example) for the disease–especially if they have risk factors that they might reduce in order to reduce the risk of a stroke?…