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Rage receptors, Taxifolin, Immunotherapy, Cilostazol-Taxifolin, and ApoA-1 as therapeutic targets for CAA
This summary of potential therapeutic targets for treating cerebral amyloid angiopathy is drawn primarily from an important review article, “Models of cerebral amyloid angiopathy-related intracerebral hemorrhage,” published by Sebastian, Vargas-George and Kunjan, R. Dave in “Brain Hemorrhages, Volume 3, Issue 4, December 2022, Pages 189-199.Here is a link to the complete article: https://www.sciencedirect.com/journal/brain-hemorrhages. Editors note:…
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“Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy”
This is a summary of a very interesting publication, with the same title as above, by Takayuki Inoue (Kyoto Medical Center), Satoshi Saito, Masashi Tanaka and edited by Lawrence Steinman (Stanford University School of Medicine). It was published April 29, 2019 in the Proceedings of the National Academy of Sciences (PNAS) 116 (20) 10031-10038Here is…
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Depression may interfere with blood pressure management after intracerebral hemorrhage
Blood pressure management (which typically means keeping average systolic pressure below 130Hg) is one of the few means of reducing the risk of intracerebral hemorrhage for patients with cerebral amyloid angiopathy (CAA). Yet, less than one-half of patients are able to achieve their necessary blood pressure targets. According to one study at Mass General Hospital,…
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Australian actor tests positive for two copies of the APOE4 gene.
Australian actor, Chris Hemsworth, tests positive for two copies of the APOE4 gene that increases risk of CAA or Alzheimers. Will this call attention to CAA, AD, and the need for life style changes in the broader public?https://www.theguardian.com/film/2022/nov/21/chris-hemsworth-to-take-time-off-from-acting-after-discovering-alzheimers-risk
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Low levels of BACE1 Inhibition might be a promising treatment for AD
The production of amyloid-β can be reduced by “…inhibitors of β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1.” Therefore, BACE1 inhibitors would seem to offer promising drug therapies for AZ (and perhaps for CAA?). Although nearly all trials have been unsuccessful and discontinued, any harmful effects are reversible. It therefore seems that treatments with lower…
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Taxifolin may be a Potential Treatment for Cerebral Amyloid Angiopathy
“Taxifolin is a plant flavonoid, widely available as a health supplement…[with] anti-oxidative and anti-inflammatory effects..[It can protect] against advanced glycation end products and mitochondrial damage…prevent oligomer formation and increase clearance of Aβ in a mouse model of CAA. Disturbed cerebrovascular reactivity and spatial reference memory impairment in CAA are completely prevented by Taxifolin treatment.” Clinical…