Blood pressure management (which typically means keeping average systolic pressure below 130Hg) is one of the few means of reducing the risk of intracerebral hemorrhage for patients with cerebral amyloid angiopathy (CAA). Yet, less than one-half of patients are able to achieve their necessary blood pressure targets. According to one study at Mass General Hospital, over one-half of their subjects actually experienced depression which, in turn, was accompanied by an increase of about 8 points in systolic pressure after onset. Following recovery from depression, blood pressure declined by a nearly equivalent amount. This suggests that it is important for clinicians to be sensitive to the potential effects of a patients mental state on blood pressure levels–because it could increase the risk of hemorrhage. Finally, the use of “selective serotonin reuptake inhibitor and noradrenaline-serotonin reuptake inhibitor” to deal with depression was found to increase the risk of higher blood pressure.