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Rage receptors, Taxifolin, Immunotherapy, Cilostazol-Taxifolin, and ApoA-1 as therapeutic targets for CAA
This summary of potential therapeutic targets for treating cerebral amyloid angiopathy is drawn primarily from an important review article, “Models of cerebral amyloid angiopathy-related intracerebral hemorrhage,” published by Sebastian, Vargas-George and Kunjan, R. Dave in “Brain Hemorrhages, Volume 3, Issue 4, December 2022, Pages 189-199.Here is a link to the complete article: https://www.sciencedirect.com/journal/brain-hemorrhages. Editors note:…
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“Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy”
This is a summary of a very interesting publication, with the same title as above, by Takayuki Inoue (Kyoto Medical Center), Satoshi Saito, Masashi Tanaka and edited by Lawrence Steinman (Stanford University School of Medicine). It was published April 29, 2019 in the Proceedings of the National Academy of Sciences (PNAS) 116 (20) 10031-10038Here is…
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Depression may interfere with blood pressure management after intracerebral hemorrhage
Blood pressure management (which typically means keeping average systolic pressure below 130Hg) is one of the few means of reducing the risk of intracerebral hemorrhage for patients with cerebral amyloid angiopathy (CAA). Yet, less than one-half of patients are able to achieve their necessary blood pressure targets. According to one study at Mass General Hospital,…
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Unraveling microinfarts and microbleeds in cerebral amyloid angiopathy
At Mass General Hospital, Susanne Janneke van Veluw, gives an impressive explanation of the pathophysiology of microinfarts and microbleeds due to CAA. Microinfarts seem to come from blood vessels that retain amyloid-beta, lose smooth muscle cells, and therefore become stiff–possibly leading to an infart. Microbleeds seem to occur when cells lose both amyloid-beta and smooth…