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Brain waste clearance to treat CAA: apolipoprotein J, and cholinergic and aginergic innervation of the smooth cells
According to Roxana Carare, MD PhD, at the University of Southampton, apolipoprotein J (also called clusterin) is being investigated for its role in chaperoning Amyloid Beta for brain waste clearance along the intramural periarterial pathway (IPAD). A second approach to improving amyloid beta clearance is via the cholinergic and aginergic innervation of the smooth cells…
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List of Expert Researchers in Cerebral Amyloid Angiopathy
Since so much research is currently being conducted on cerebral amyloid angiopathy, it may be useful to know some of the widely published researchers, where they are working, and the themes of their best research papers. Here is a link to findexpertmd.com: https://findexpertmd.com/d/Cerebral_Amyloid_Angiopathy
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Systolic blood pressure below 120mmHG reduces hemorrhage stroke risk by 25%
According to a recently published review of 1800 cases of spontaneous intracerebral hemorrhage (ICH) which were followed over approximately four years, the risk of a ICH recurrence fell by about 25% when systolic blood pressure was maintained below 120mmHG (.75 hazard ration), as compared with blood pressure maintenance in the slightly higher 120-130mmHG range. Our…
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Unraveling microinfarts and microbleeds in cerebral amyloid angiopathy
At Mass General Hospital, Susanne Janneke van Veluw, gives an impressive explanation of the pathophysiology of microinfarts and microbleeds due to CAA. Microinfarts seem to come from blood vessels that retain amyloid-beta, lose smooth muscle cells, and therefore become stiff–possibly leading to an infart. Microbleeds seem to occur when cells lose both amyloid-beta and smooth…
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Convexity subarachnoid but not subdural hemorrhages associated with CAA
In labor hemorrhage survivors, a newly published study from Toulouse, France shows that subarachnoid but not subdural hemorrhages are associated With Cerebral Amyloid Angiopathy (CAA).https://pubmed.ncbi.nlm.nih.gov/31136281/
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PSMD may be a promising new test for CAA
A rather technical-sounding measure called “Peak Width of Skeletonized Mean Diffusivity” (PSMD) has been proposed as a measure of brain injury. According to an article in published in “Frontiers in Neuroscience,” this measure – a variant on conventional MRI – may be able to distinguish between injury caused by cerebral amyloid angiopathy (CAA) or arteriosclerosis.…
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Important News: The Flu Vaccine May Protect Against Cognitive Impairment!
An annual flu shot seems to be protective not only against the flu but against Alzheimer’s disease–and possibly against the cognitive effects of CAA (Cerebral Amyloid Angiopathy). Here is a link to this research:https://www.webmd.com/vaccines/news/20220630/flu-vaccine-older-minds-sharp-study According to WebMD, “In a large study of vaccinated and unvaccinated adults ages 65 and older, those who received at least…
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Hallucinations after Stroke: The Experience of One Patient
Patient A.D., a physical fit senior woman, suffered a bleeding stroke, attributed to Cerebral Amyloid Angiopathy, in her left occipital lobe. (This is where visual information is processed.) As a result, she lost vision in the right half of each eye, a condition called Homonymous Hemianopia. Hallucinations of Giant Flowers and People. While recovering at…
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Foods choices to limit amyloids
Vegetarian diet and avoiding processed meat slows amyloid beta build up in brain.
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To test or not to test –Cerebral Amyloid Angiopathy (CAA).
CAA is a serious age-related condition that may be discovered only after a hemorrhagic stroke followed by an MRI. Since MRI’s are not exceedingly expensive, why not test seniors (over age 75 for example) for the disease–especially if they have risk factors that they might reduce in order to reduce the risk of a stroke?…